A Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling
https://www.biorxiv.org/content/10.1101/2023.02.15.528618v1
great work by the whole team!
Welcome to the website for the Trost Laboratory
https://www.biorxiv.org/content/10.1101/2023.02.15.528618v1
great work by the whole team!
Ritika Chatterjee has joined us as an expert in infection biology to study host-pathogen interactions on the phagosome!
Welcome, Ritika!
A warm welcome to our NU undergraduates Ellie and Sava as well as our undergraduates from Madrid, Mark and Ruben!
We have two industrially funded PhD studentships available within the EPSRC-funded Mosmed CDT with start date in Sept 2023.
Applicants should be interested/experienced in mass spectrometry. Usually, we would expect applicants to have a masters.
The first project is with GSK to develop exciting “Mass spectrometry approaches to address capability gaps in drug discovery for membrane transporters”.
There will be a placement at GSK and the use of exciting novel technology.
Maria led the writing of this wonderful review in EMBO Mol Medicine together with colleagues from GSK (including our own ex-student Rachel Heap) and BI.
Read it here:
A new amazing paper on how lysosomal damage through Mtb drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
Tiaan did the cool mass spec for this!
…and Maria’s first last-author paper!
A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1
https://slas-discovery.org/article/S2472-5552(22)13707-X/fulltext
Characterising the role of ubiquitylation in endo-lysosomal trafficking by highly sensitive ion mobility mass spectrometry
We are looking for a talented PhD student to join us in September 2023. Exciting novel technology, exciting, impactful biology. Apply online and send an email to Matthias to discuss.
Congratulations to Jack and Jose for publishing this great review on the role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer.
See the open access article here: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012002/full