Trost Lab

Finally out! A great paper by amazing postdocs Olivier and Anetta.

Govaere, O., Martinez-Lopez, N., Kragh Petersen, S., Mancina, R.M., Bel Lassen, P., Darlay, R., Peltier, J., Younes, R., Tiniakos, D., Aithal, G.P., Allison, M., Vacca, M., Yki-Järvinen, H., Dufour, J.-F., Ekstedt, M., Francque, S., Petta, S., Bugianesi, E., Schattenberg, J.M, Day, C.P., Cordell, H.J, Clément, K., Romeo, S., Ratziu, V., Daly, A.K., Anstee, Q.M*, Trost, M.*, Härtlova, A.*, Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in human obesity-related non-alcoholic fatty liver disease, (2021), Journal of Hepatology, Dec 20:S0168-8278(21)02254-6. Link

A nice collaboration with Chris Duncan’s lab on “Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2” has just been published in Nature Communications.

Congratulations to all involved, particularly, Maria who led this work from our lab!

Hatton, C.F*, Botting, R.A.*, Dueñas, M.E.*, Haq, I.J., Verdon, B., Thompson, B.J., Stremenova Spegarova, J., Gothe, F., Stephenson, E., Gardner, A.I., Murphy, S., Scott, J., Garnett, J.P., Carrie, S., Hussain, R., Coxhead, J., Davey, T., Simpson, A.J., Haniffa, M., Hambleton, S., Brodlie, M., Ward, C., Trost, M., Reynolds, G., Duncan, C.J.A, Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2, (2021) Nature Communications Dec 7;12(1):7092. (*co-first authors)

 

A warm welcome to Andrew Frey who has joined us to work with us on the role of ubiquitylation on the phagosome!

A warm welcome to Benjamin Raymond who joined us this week. Benjamin will work on characterising the ubiquitylation on the phagosome.

We have a postdoc position open in clinical proteomics to work with excellent clinicians in cancer, mitochondrial disease and immune related diseases.

mass spec/proteomics experience essential.

apply here: https://jobs.ncl.ac.uk/job/Newcastle-Research-AssociateAssistant/718679201/

Great paper by Marzena et al. Rachel and Anetta helped with proteomics samples.

Altered ceramide metabolism is a feature in the extracellular
vesicle‑mediated spread of alpha‑synuclein in Lewy body disorders

pdf available here: Kurzawa-Akanbi2021_Article_AlteredCeramideMetabolismIsAFe

 

Latest preprint from our lab. The E3 ligase RNF115 regulates phagosome maturation and host response to bacterial infection

Congratulations to all authors to this nice work!

https://www.biorxiv.org/content/10.1101/2021.07.13.452284v1

We have an exciting 3-year PhD studentship focussing on proteomics characterisation of novel tyrosine kinase inhibitors against leukemia.

This project will be supervised by the dream team of José and Maria.

UK and EU residents are eligible.

Start date ideally this September.

https://www.ncl.ac.uk/postgraduate/funding/sources/allstudents/bi042.html 

Email Matthias for questions!