A warm welcome to our three new PhD students starting this September!

Meihan is a BBSRC iCASE student and will use highly sensitive mass spectrometry approaches to study ubiquitylation in the eno-lysosomal system.

Mengchun is a GSK-funded student within the MosMed DTP and will develop mass spectrometry approaches to address capability gaps in drug discovery for membrane transporters.

Simran is a Boehringer Ingelheim-funded student within the MosMed DTP and will utilise proteomics approaches in characterising disease models in inflammatory bowel disease and develop novel approaches for drug deconvolution.

We just said goodbye to our fantastic postdocs Maria Dueñas and José Luis Marin Rubio who move to the University of Perth (Australia) and the Memorial Sloan Kettering Cancer Center in New York, respectively!

We are extremely grateful for their amazing work and wish them good luck for the future!

Great collaboration with the Cousin Lab in Edinburgh! check the paper out here:

Bonnycastle, K., Dobson, K.L., Blumrich, E.M., Gajbhiye, A., Davenport, E.C., Pronot, M., Steinruecke, M., Trost, M., Gonzalez-Sulser, A., Cousin, M.A., Reversal of cell, circuit and seizure phenotypes in DNM1 epileptic encephalopathy,(2023) Nature Communications Aug 30;14(1):5285. doi: 10.1038/s41467-023-41035-w.

Congratulations to Amy for publishing her first first-author paper “A benchmark of LFQ-DIA against  current TMT-DDA multiplexing approaches for thermal proteome profiling (TPP) using losmapimod in AML. ” in Journal of Proteome Research!

Great collaborations with the van den Berg-Lab and Lowe-Lab leading to fantastic papers in Nature and Nature Communications, respectively!

Super work from Tiaan and Andy! Well done!

Abellon-Ruiz, J., Jana, K., Silale, A., Frey, A., Baslé, A., Trost, M., Kleinekathöfer, U., and van den Berg, B., BtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B12 uptake in gut Bacteroides. (2023), Nature, Jun;618(7965):583-589.

Al-Jourani, O., Benedict,, Ross, J., Layton, A., van der Peet, P., Marando, V.M., Bailey, N.P., Heunis, T., Manion, J., Mensitieri, F., Franklin, A., Abellon-Ruiz, J., Oram, S.L., Parsons, L., Cartmell, A., Wright, G.S.A., Baslé, A., Trost, M., Henrissat, B., Munoz-Munoz, J., Hirt, R.P., Kiessling, L.L., Lovering, A., Williams, S.J., Lowe, E.C., Moynihan, P.J., Mining the human gut microbiome identifies mycobacterial D-arabinan degrading enzymes, (2023), Nature Comm, Apr 19;14(1):2233.

A Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling

https://www.biorxiv.org/content/10.1101/2023.02.15.528618v1

great work by the whole team!

Ritika Chatterjee has joined us as an expert in infection biology to study host-pathogen interactions on the phagosome!

Welcome, Ritika!

A warm welcome to our NU undergraduates Ellie and Sava as well as our undergraduates from Madrid, Mark and Ruben!

We have two industrially funded PhD studentships available within the EPSRC-funded Mosmed CDT with start date in Sept 2023.

Applicants should be interested/experienced in mass spectrometry. Usually, we would expect applicants to have a masters. 

The first project is with GSK to develop exciting “Mass spectrometry approaches to address capability gaps in drug discovery for membrane transporters”.

There will be a placement at GSK and the use of exciting novel technology.