Matthias Trost on Google Scholar
https://orcid.org/0000-0002-5732-700X
2024
George, A.L., Dueñas, M.E., Marín-Rubio, J.L, Trost, M., Stability-based approaches in chemoproteomics, (2024) Expert Rev Mol Med 2024 Apr 12:26:e6. doi: 10.1017/erm.2024.6.
Gudgeon, J., Marin-Rubio, J.L., Sidgwick, F., Trost, M., Mass spectrometry-based proteomic exploration of diverse murine macrophage cellular models, bioRxiv 2024.04.09.588684; doi: https://doi.org/10.1101/2024.04.09.588684
Hermosilla-Trespaderne, M., Hu-Yang, M.X., Dannoura, A., Frey, A.M., George, A.L., Trost, M.*, Marin-Rubio, J.L.*, Proteomic Analysis Reveals Trilaciclib-Induced Senescence, bioRxiv, 2024.03. 12.584620
Raymond, B.B.A., Frey, A.M., Trost, M., Proteomic mapping of macrophages in response to the clearance of apoptotic cells reveals a unique reprogramming profile, bioRxiv, doi: https://doi.org/10.1101/2023.11.23.567533
2023
Bonnycastle, K., Dobson, K.L., Blumrich, E.M., Gajbhiye, A., Davenport, E.C., Pronot, M., Steinruecke, M., Trost, M., Gonzalez-Sulser, A., Cousin, M.A., Reversal of cell, circuit and seizure phenotypes in DNM1 epileptic encephalopathy,(2023) Nature Communications Aug 30;14(1):5285. doi: 10.1038/s41467-023-41035-w.
Méndez-Alejandre A, Raymond BBA, Trost M, Marín-Rubio JL. Bi-functional particles for real-time phagosome acidification and proteolysis multiplex assay in macrophages. (2023) Front Immunol. 2023 Aug 10;14:1204223. doi: 10.3389/fimmu.2023.1204223.
White, J.B.R., Silale, A., Feasey, M., Heunis, T., Zhu, Y., Zheng, H., Gajbhiye, A., Firbank, S., Baslé, A., Trost, M., Bolam, D.N., van den Berg, B., Ranson, N.A. Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes. (2023) Nature, Jun;618(7965):583-589.
Dueñas ME, Marín-Rubio JL, Peltier-Heap J, Hartlova A, Trost M. Assessing the Phagosome Proteome by Quantitative Mass Spectrometry. (2023) Methods Mol Biol. 2023;2692:361-374.
Raymond BBA, Inns J, Frey AM, Trost M. Isolation of Polystyrene Bead-Induced Phagosomes for Western Blotting. (2023) Methods Mol Biol. 2023;2692:237-246.
Abellon-Ruiz, J., Jana, K., Silale, A., Frey, A., Baslé, A., Trost, M., Kleinekathöfer, U., and van den Berg, B., BtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B12 uptake in gut Bacteroides. (2023), Nature Communications, 2023 Aug 5;14(1):4714.
Al-Jourani, O., Benedict,, Ross, J., Layton, A., van der Peet, P., Marando, V.M., Bailey, N.P., Heunis, T., Manion, J., Mensitieri, F., Franklin, A., Abellon-Ruiz, J., Oram, S.L., Parsons, L., Cartmell, A., Wright, G.S.A., Baslé, A., Trost, M., Henrissat, B., Munoz-Munoz, J., Hirt, R.P., Kiessling, L.L., Lovering, A., Williams, S.J., Lowe, E.C., Moynihan, P.J., Mining the human gut microbiome identifies mycobacterial D-arabinan degrading enzymes, (2023), Nature Communications, Apr 19;14(1):2233.
George, A.L., Sidgwick, F.R., Watt, J.E., Martin, M.P., Trost, M.*, Marín-Rubio, J.L.*, Dueñas, M.E.* A benchmark of LFQ-DIA against current TMT-DDA multiplexing approaches for thermal proteome profiling (TPP) using losmapimod in AML. (2023) Journal of Proteome Research 2023 Aug 4; 22(8):2629-2640
Dueñas, M.E., Peltier-Heap, R.E., Leveridge, M., Annan, R.S., Büttner, F.H. and Trost, M., Advances in high-throughput mass spectrometry in drug discovery, (2023) EMBO Mol Medicine, e14850 Link
2022
Marín-Rubio JL, Vela-Martín L, Gudgeon J, Pérez-Gómez E, Sidgwick FR, Trost M, Cunningham DL, Santos J, Fernández-Piqueras J, Villa-Morales M. A Dual Role for FADD in Human Precursor T-Cell Neoplasms. (2022) Int J Mol Sci, 2022 Dec 2;23(23):15157.
Bussi, C., Heunis, T., Pellegrino, E., Bernard, E.M., Bah, N., Silva dos Santos, M., Santucci, P., Aylan, B., Rodgers, A., Fearns, A., Mitschke, J., Moore, C., MacRae, J.I., Greco, M., Reinheckel, T., Trost, M., and Gutierrez, M.G., Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism, (2022) Nature Communications, 2022 Nov 28;13(1):7338. Link
Müller, L., Burton, A.K., Tayler, C.L, Rowedder, J.E., Hutchinson, J.P., Peace, S., Quayle, J.M., Leveridge, M.V., Annan, R.S., Trost, M.*, Peltier-Heap, R.E.* and Dueñas, M.E.*, A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1, (2022) SLAS Discovery, Nov 19;S2472-5552(22)13707-X. Link
Bilkei-Gorzo, O., Heunis, T., Marín-Rubio, J.L., Cianfanelli, F.R., Raymond, B.B.A., Inns, J., Fabrikova, D., Peltier, J., Oakley, F., Schmid, R., Härtlova, A.*, Trost, M.*, The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection, (2022), EMBO Journal, e108970 https://doi.org/10.15252/embj.2021108970
Gudgeon, J., Marín-Rubio, J.L., Trost, M., Role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer (2022), Frontiers in Immunology, doi: 10.3389/fimmu.2022.1012002
Gajbhiye, A., Nalbant, A., Heunis, T., Sidgwick, F., Porter, A., Taha, Y., Trost, M., A fast and sensitive absolute quantification assay for the detection of SARS-CoV-2 peptides using Parallel Reaction Monitoring Mass Spectrometry,(2022) J Proteomics, 2022 Aug 15;265:104664.
Govaere, O., Martinez-Lopez, N., Kragh Petersen, S., Mancina, R.M., Bel Lassen, P., Darlay, R., Peltier, J., Younes, R., Tiniakos, D., Aithal, G.P., Allison, M., Vacca, M., Yki-Järvinen, H., Dufour, J.-F., Ekstedt, M., Francque, S., Petta, S., Bugianesi, E., Schattenberg, J.M, Day, C.P., Cordell, H.J, Clément, K., Romeo, S., Ratziu, V., Daly, A.K., Anstee, Q.M*, Trost, M.*, Härtlova, A.*, Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in human obesity-related non-alcoholic fatty liver disease, Link
2021
Brown, H.A., Williams, C.A.C., Zhou, H., Rios-Szwed, D., Fernandez-Alonso, R., Mansoor, S., McMulkin, L., Toth, R., Gourlay, R., Peltier, J., Dieguez-Martinez, N., Trost, M., Lizcano, J.M., Stavridis, M.P., Findlay, G.M. An ERK5-KLF2 signalling module regulates early embryonic gene expression dynamics and stem cell rejuvenation, (2021) Biochem Journal, Dec 10;478(23):4119-4136.
Hatton, C.F.#, Botting, R.A.#, Dueñas, M.E.#, Haq, I.J., Verdon, B., Thompson, B.J., Stremenova Spegarova, J., Gothe, F., Stephenson, E., Gardner, A.I., Murphy, S., Scott, J., Garnett, J.P., Carrie, S., Hussain, R., Coxhead, J., Davey, T., Simpson, A.J., Haniffa, M., Hambleton, S., Brodlie, M., Ward, C.*, Trost, M.*, Reynolds, G.*, Duncan, C.J.A*, Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2, (2021) Nature Communications Dec 7;12(1):7092.
Kurzawa-Akanbi, M., Tammireddy, S., Fabrik, I., Gliaudelyté, L., Doherty, M.K., Heap, R., Trost, M., Lucocq, J.M., Gherman, A.V., Matečko-Burmann, I., Burmann, B.M., Fairfoul, G., Singh, P., Burté, F., Green, A., McKeith, I.G., Härtlova, A., Whitfield, P.D., Morris, C.M. (2021), Altered ceramide metabolism is a feature in the extracellular vesicle mediated spread of alpha-synuclein in sporadic and GBA-linked Lewy body disease. Acta Neuropathologica Sep 13. doi: 10.1007/s00401-021-02367-3. paper here: Kurzawa-Akanbi2021_Article_AlteredCeramideMetabolismIsAFe
Ivanova, D., Dobson, K.L., Gajbhiye, A., Davenport, E.C., Hacker, D., Ultanir, S., Trost, M. and Cousin, M.A., Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes, (2021) Science Advances, Apr 30;7(18):eabf3873.
Heap RE, Marín-Rubio JL, Peltier J, Heunis T, Dannoura A, Moore A, Trost M. Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation. (2021) Life Sci Alliance Apr 14;4(6):e202000957.
Queval, C.J., Fearns, A., Botella, L., Smyth A., Schnettger, L., Mittermite, M., Villarreal-Ramos, B., Pacey, K., Garcia-Jimenez, W., Heunis, T., Trost, M., Werling, D., Salguero, F.J., Gordon, S.V and Gutierrez, M.G. Extracellular vesicles from Mycobacterium bovis infected bovine macrophages promote multinucleated cell formation (2021) PLOS Pathogens, Mar 15;17(3):e1009410
Breyer, F., Härtlova, A., Thurston, T., Flynn, H.R., Chakravarty, P., Janzen, J., Peltier, J., Heunis, T., Snijders, A.P., Trost, M. and Ley, S.C. TPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria, (2021) EMBO Journal, e106188
2020
De Cesare V., Moran J., Traynor R., Knebel A., Ritorto M.S., Trost M., McLauchlan H., Hastie C.J., Davies P. High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry-based deubiquitylating enzyme assay for drug discovery. Nature Protocols. 2020 Nov 2. doi: 10.1038/s41596-020-00405-0. Epub ahead of print. PMID: 33139956. Link
Leslie, J., Macia, M. G., Luli, S., Worrell, J. C., Reilly, W. J., Paish, H. L., Knox, A., Barksby, B. S., Gee, L. M., Zaki, M. Y. W., Collins, A. L., Burgoyne, R. A., Cameron, R., Bragg, C., Xu, X., Chung, G. W., Brown, C. D. A., Blanchard, A. D., Nanthakumar, C. B., Karsdal, M., Robinson, S. M., Manas, D. M., Sen, G., French, J., White, S. A., Murphy, S., Trost, M., Zakrzewski, J. L., Klein, U., Schwabe, R. F., Mederacke, I., Nixon, C., Bird, T., Teuwen, L.-A., Schoonjans, L., Carmeliet, P., Mann, J., Fisher, A. J., Sheerin, N. S., Borthwick, L. A., Mann, D. A., and Oakley, F. (2020) c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis, (2020) Nature Metabolism. https://doi.org/10.1038/s42255-020-00306-2
Ulhuq FR, Gomes MC, Duggan GM, Guo M, Mendonca C, Buchanan G, Chalmers JD, Cao Z, Kneuper H, Murdoch S, Thomson S, Strahl H, Trost M, Mostowy S, Palmer T. A membrane-depolarizing toxin substrate of the Staphylococcus aureus type VII secretion system mediates intraspecies competition. Proc Natl Acad Sci U S A. 2020 Aug 7:202006110. doi: 10.1073/pnas.2006110117.
https://www.pnas.org/content/early/2020/08/06/2006110117
Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ. USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. Life Sci Alliance. 2020 Jul 7;3(8):e202000768. doi: 10.26508/lsa.202000768. https://doi.org/10.26508/lsa.202000768
Trost M. Supporting the UK National Health Service during the COVID-19 crisis from an academic perspective Nat Med. 2020 Jul;26(7):989. doi: 10.1038/s41591-020-0885-5. https://www.nature.com/articles/s41591-020-0885-5
Heunis, T., Lamoliatte, F., Marín-Rubio, J.L., Dannoura, A., Trost, M., Targeted Proteomic Analysis Reveals Enrichment of Atypical Ubiquitin Chains in Contractile Tissues, J Proteomics. 2020 Sep 6;229:103963. doi: 10.1016/j.jprot.2020.103963. Link
2019
Malik N, Nirujogi RS, Peltier J, Macartney T, Wightman M, Prescott AR, Gourlay R, Trost M, Alessi DR, Karapetsas A., Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44. Biochem J. 2019 Oct 30;476(20):3081-3107. doi: 10.1042/BCJ20190608. Link
Heap, R.E., Segarra Fas, A., Blain, A.P., Findlay, G.M. and Trost, M., Profiling embryonic stem cell differentiation by MALDI-MS: development of a reproducible and robust sample preparation workflow. (2019) Analyst, DOI: 10.1039/c9an00771g Link
Guo, M., Härtlova, A., Gierliński, M., Prescott, A.R., Castellvi, J., Hernandez Losa, J., Dill, B.D., Emmerich, C., Ritorto, M.S., Barton, G.J., Russell, D.G., Ramon Y Cajal, S. and Trost, M. Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages, (2019) EMBO Journal, Jun 3;38(11). pii: e100299. doi: 10.15252 Link
Pauwels, A.M., Härtlova, A., Peltier, J., Driege, Y., Baudelet, G., Brodin, P., Trost, M., Beyaert, R., and Hoffmann, E., Spatiotemporal changes of the phagosomal proteome in dendritic cells in response to LPS stimulation, (2019) Mol Cell Proteomics, May;18(5):909-922. doi: 10.1074/mcp.RA119.001316 Link
Keuss, M.J., Hjerpe, R., Hsia, O., Gourlay, R., Burchmore, R., Trost, M. and Kurz, T., DEN1/NEDP1/SENP8 cleaves NEDD8 chains to regulate PARP1 dependent cell death and Cullin-RING E3 ubiquitin ligase activity, (2019) EMBO Journal, DOI 10.15252/embj.2018100024 LInk
Hansen, M., Peltier, J., Killy, B., Amin, B., Bodendorfer, B., Härtlova, A., Uebel, S., Bosmann, M., Hofmann, J., Büttner, C., Ekici, A.B., Kuttke, M., Franzyk, H., Foged, C. Beer-Hammer, S., Schabbauer, G., Trost, M., Lang, R., Combined phosphoproteome and transcriptome analysis of the response to mycobacterial cord factor reveals a dichotomy of Mincle-dependent and -independent signaling in macrophages, (2019) Mol Cell Proteomics, Jan 11 Epub Link
2018
Dean, P., Heunis, T., Härtlova, A., Trost, M., Post-translational control of phagosome functions, Curr Opin Chem Biol, (2018) paper here: Dean2018(regulation of phagosome functions by post-translational modifications -REV)
A., Muñoz-Muñoz, J., Briggs, J., Ndeh, D.A., Lowe, E.C., Baslé, A., Terrapon, N., Stott, K., Heunis, T., Gray, J., Yu, L., Dupree, P., Fernandes, P.Z., Shah, S., Williams, S.J., Labourel, A., Trost, M., Henrissat, B. and Gilbert, H.J, The cellular location of endo-acting galactanases confers keystone or recipient status to arabinogalactan degrading organisms of the human gut microbiota, (2018) Nature Microbiology, Oct 22 https://www.nature.com/articles/s41564-018-0258-8
Kokotos A.C., Peltier J., Davenport E.C., Trost M., Cousin M.A. The activity-dependent bulk endocytosis proteome reveals a key presynaptic role for Rab11, (2018) Proc Natl Acad Sci USA, Oct 9. pii: 201809189. doi: 10.1073/pnas.1809189115 http://www.pnas.org/content/115/43/E10177.long
Muñoz, I.M., Morgan, M.E., Peltier, J., Weiland, F., Gregorczyk, M., Macartney, T., Brown, F., Toth, R., Trost, M.* and Rouse, J.*, Phosphoproteomic screening identifies cytoskeleton regulators as novel targets of the CDKL5 kinase, (2018) EMBO Journal (*corresponding authors) Sep 28. pii: e99559. doi: 10.15252/embj.201899559 http://emboj.embopress.org/content/early/2018/09/28/embj.201899559.long
de las Pozas, A., Reiner, T., De Cesare, V., Trost, M. and Perez-Stable, C., Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells, (2018) Scientific Reports, 8:13146 https://www.nature.com/articles/s41598-018-31567-3
Ostrowski, A., Cianfanelli, F.R., Porter, M., Peltier, J., Wong, J., Swedlow, J.R., Trost, M. and Coulthurst, S.J., Integrated post-translational regulation of an offensive Type VI secretion system, (2018) PLOS Pathogens, Jul 27;14(7) Link
Trunk, K., Peltier, J., Liu, Y.-C., Dill, B., Walker, L., Gow, N.A.R., Stark, M.J.R., Quinn, J, Strahl, H., Trost, M.* and Coulthurst, S.J.*, Targeting a new kingdom: anti-fungal effectors delivered by the Type VI secretion system, (2018) Nature Microbiology (*corresponding authors) Aug;3(8):920-931. Link
De Cesare, V., Johnson, C., Barlow, V., Hastie, J., Knebel, A. and Trost, M., The MALDI TOF E2/E3 ligase assay for drug discovery, (2018) Cell Chem Biol, July 12 Link
Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M*, Gutierrez MG*. LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. EMBO Journal (2018) May 22. pii: e98694. doi: 10.15252/embj.201798694. https://www.ncbi.nlm.nih.gov/pubmed/29789389
Miettinen, T.P., Peltier, J., Härtlova, A., Gierliński, M., Jansen, V.M., Trost, M.* and Björklund, M.*, Thermal profiling of breast cancer cells identifies the proteasome as a target for CDK4/6 inhibitor palbociclib, EMBO Journal (2018) Apr 18. pii: e98359. doi: 10.15252/embj.201798359 https://www.ncbi.nlm.nih.gov/pubmed/29669860
2017
Kategaya, L., Di Lello, P., Rougé, L., Pastor, R., Clark, K.R., Drummond, J., Kleinheinz, T., Lin, E., Upton, J.P., Prakash, S., Heideker, J., McCleland, M., Ritorto, M.S., Bainbridge, T.W., Ma, T.P, Kwok, M.C.M, Stiffler, Z., Brasher, B., Alessi, D.R., Trost, M., Renslo, A.R., Arkin, M.R., Cohen, F., Yu, K., Peale, F., Gnad, F., Chang, M.T., Klijn, C., Blackwood, E., Martin, S.E., Forrest, W.F., Ernst, J.A., Ndubaku, C., Wang, X., Beresini, M.H., Tsui, V., Schwerdtfeger, C., Blake, R.A., Murray, J., Maurer, T. and Wertz, I.E., USP7 Small Molecule Inhibitors Interfere with Ubiquitin Binding, Nature (2017), Oct 26;550(7677):534-538 https://www.ncbi.nlm.nih.gov/pubmed/29045385
Heap, R.E., Hope, A., Pearson, L.A., Reyskens, K.M.S.E., MacGowan, S., Hastie, J., Porter, D., Arthur, J.S.C, Gray, D.W. and Trost, M., Identifying inhibitors of Inflammation: A novel high-throughput MALDI-TOF screening assay for salt inducible kinases (SIKs), SLAS Discovery (2017) https://www.ncbi.nlm.nih.gov/pubmed/28692323
Selvan, N., Williamson, R., Mariappa, D., Campbell, D.G., Gourlay, R., Ferenbach, A.T., Aristotelous, T., Hopkins-Navratilova, I., Trost, M. and van Aalten, D.M.F., Native enrichment of the Drosophila O-GlcNAc proteome reveals candidate conveyors of the supersex combs phenotype, Nature Chem Biol (2017), Jun 12. https://www.ncbi.nlm.nih.gov/pubmed/28604694
Pauwels, A.-M., Trost, M., Beyaert, R. and Hoffmann, E., Patterns, Receptors and Signals: Regulation of Phagosome Maturation, Trends in Immunology (2017), Jun;38(6):407-422 https://www.ncbi.nlm.nih.gov/pubmed/28416446
Magiera, K., Tomala, M., Kubica, K., De Cesare, V., Trost, M., Zieba, B.J., Kachamakova-Trojanowska, N., Les, M., Dubin, G., Holak, T.A. and Skalniak, L. Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a, Cell Chem Biol (2017), Apr 20;24(4):458-470. https://www.ncbi.nlm.nih.gov/pubmed/28343940
| Hartlova, A., Peltier, J., Bilkei-Gorzo, O. and Trost, M. (2017). Isolation and Western Blotting of Latex-Bead Phagosomes to Track Phagosome Maturation. Methods Mol Biol (2017) 1519, pp. 241-248 https://www.ncbi.nlm.nih.gov/pubmed/27815884 |
Peltier, J., Hartlova, A. and Trost, M. (2017). Assessing the Phagosome Proteome by Quantitative Mass Spectrometry. Methods Mol Biol (2017) 1519, pp. 249-263 https://www.ncbi.nlm.nih.gov/pubmed/27815885
2016
Cianfanelli, F. R., Alcoforado Diniz, J., Guo, M., De Cesare, V., Trost, M. and Coulthurst, S. J.(2016). VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System. PLoS Pathog (2016) 12, pp. e1005735 https://www.ncbi.nlm.nih.gov/pubmed/27352036
Gandin, V., Masvidal, L., Cargnello, M., Gyenis, L., McLaughlan, S., Cai, Y., Tenkerian, C., Morita, M., Balanathan, P., Jean-Jean, O., Stambolic, V., Trost, M., Furic, L., Larose, L., Koromilas, A. E., Asano, K., Litchfield, D., Larsson, O. and Topisirovic, I. (2016). mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nature Commun 7, pp. 11127 https://www.ncbi.nlm.nih.gov/pubmed/27040916
Hjerpe, R., Bett, J. S., Keuss, M. J., Solovyova, A., McWilliams, T. G., Johnson, C., Sahu, I., Varghese, J., Wood, N., Wightman, M., Osborne, G., Bates, G. P., Glickman, M. H., Trost, M., Knebel, A., Marchesi, F. and Kurz, T. (2016). UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome. Cell 166, pp. 935-49 https://www.ncbi.nlm.nih.gov/pubmed/27477512
Huguenin-Dezot, N., De Cesare, V., Peltier, J., Knebel, A., Kristaryianto, Y. A., Rogerson, D. T., Kulathu, Y., Trost, M.* and Chin, J. W.* (2016). Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity. Cell Rep 16, pp. 1180-1193 https://www.ncbi.nlm.nih.gov/pubmed/27425610
McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weibeta, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L., Trost, M. and Arthur, J. S. (2016). Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation. Sci Rep 6, pp. 31159 https://www.ncbi.nlm.nih.gov/pubmed/27498693
Naujoks, J., Tabeling, C., Dill, B. D., Hoffmann, C., Brown, A. S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H. J., Dorhoi, A., Kershaw, O., Gruber, A. D., Sander, L. E., Witzenrath, M., Herold, S., Nerlich, A., Hocke, A. C., van Driel, I., Suttorp, N., Bedoui, S., Hilbi, H., Trost, M. and Opitz, B. (2016). IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid. PLoS Pathog 12, pp. e1005408 https://www.ncbi.nlm.nih.gov/pubmed/26829557
Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. and Mann, M. (2016). Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases. Elife 5, pp. e12813 https://www.ncbi.nlm.nih.gov/pubmed/26824392
Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. and Hay, R. T. (2015). Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers. Biochem J 466, pp. 489-498 https://www.ncbi.nlm.nih.gov/pubmed/25489924
2015
Dill, B. D., Gierlinski, M., Hartlova, A., Arandilla, A. G., Guo, M., Clarke, R. G. and Trost, M.(2015). Quantitative proteome analysis of temporally resolved phagosomes following uptake via key phagocytic receptors. Mol Cell Proteomics 14, pp. 1334-1349 https://www.ncbi.nlm.nih.gov/pubmed/25755298
Guo, M., Hartlova, A., Dill, B. D., Prescott, A. R., Gierlinski, M. and Trost, M. (2015). High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow derived macrophages. Proteomics 15, pp. 3169-3174 https://www.ncbi.nlm.nih.gov/pubmed/25504905
Kazlauskaite, A., Martinez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. and Muqit, M. M. (2015). Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. EMBO Rep 16, pp. 939-954 https://www.ncbi.nlm.nih.gov/pubmed/26116755
Lai, Y. C., Kondapalli, C., Lehneck, R., Procter, J. B., Dill, B. D., Woodroof, H. I., Gourlay, R., Peggie, M., Macartney, T. J., Corti, O., Corvol, J. C., Campbell, D. G., Itzen, A., Trost, M.* and Muqit, M. M.* (2015). Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO Journal 34, pp. 2840-61 https://www.ncbi.nlm.nih.gov/pubmed/26471730
2014
Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. and Watts, C. (2014). A crucial role for beta2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells. J Cell Sci 127, pp. 4213-4224 https://www.ncbi.nlm.nih.gov/pubmed/25086067
Hamilton, J. J., Marlow, V. L., Owen, R. A., Costa Mde, A., Guo, M., Buchanan, G., Chandra, G., Trost, M., Coulthurst, S. J., Palmer, T., Stanley-Wall, N. R. and Sargent, F. (2014). A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens. J Cell Biol 207, pp. 615-626 https://www.ncbi.nlm.nih.gov/pubmed/25488919
Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. and Muqit, M. M. (2014). Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. Biochem J 460, pp. 127-139 https://www.ncbi.nlm.nih.gov/pubmed/24660806
Navarro, M. N., Feijoo-Carnero, C., Arandilla, A. G., Trost, M. and Cantrell, D. A. (2014). Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naive CD8+ T cells. Science Signal 7, pp. ra99 https://www.ncbi.nlm.nih.gov/pubmed/25336615
Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R. and Trost, M. (2014). Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nature Commun 5, pp. 4763 https://www.ncbi.nlm.nih.gov/pubmed/25159004
Tape, C. J., Worboys, J. D., Sinclair, J., Gourlay, R., Vogt, J., McMahon, K. M., Trost, M., Lauffenburger, D. A., Lamont, D. J. and Jorgensen, C. (2014). Reproducible automated phosphopeptide enrichment using magnetic TiO2 and Ti-IMAC. Anal Chem 86, pp. 10296-10302 https://www.ncbi.nlm.nih.gov/pubmed/25233145
2013
Edgar, A. J., Trost, M., Watts, C. and Zaru, R. (2013). A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870. Biosci Rep https://www.ncbi.nlm.nih.gov/pubmed/24341623
Fritsch, M. J., Trunk, K., Diniz, J. A., Guo, M., Trost, M.* and Coulthurst, S. J. * (2013). Proteomic identification of novel secreted antibacterial toxins of the Serratia marcescens type VI secretion system. Mol Cell Proteomics 12, pp. 2735-2749 https://www.ncbi.nlm.nih.gov/pubmed/23842002
Ritorto, M. S., Cook, K., Tyagi, K., Pedrioli, P. G. and Trost, M. (2013). Hydrophilic Strong Anion Exchange (hSAX) Chromatography for Highly Orthogonal Peptide Separation of Complex Proteomes. J Proteome Res 12, pp. 2449-2457 https://www.ncbi.nlm.nih.gov/pubmed/23294059
Ritorto, M. S., Trost, M. and Cook, K. (2013). Hydrophilic strong anion exchange chromatography for proteomics: what’s the future outlook?. Bioanalysis 5, pp. 2219-2221 https://www.ncbi.nlm.nih.gov/pubmed/24053235
M Trost Papers before Trost-lab:
Trost, M.,* Sauvageau, M.,* Herault, O., Deleris, P., Pomies, C., Chagraoui, J., Mayotte, N., Meloche, S., Sauvageau, G. and Thibault, P. (2012). Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, pp. e17-27 https://www.ncbi.nlm.nih.gov/pubmed/22802335
Campbell-Valois, F. X.,* Trost, M.,* Chemali, M., Dill, B. D., Laplante, A., Duclos, S., Sadeghi, S., Rondeau, C., Morrow, I. C., Bell, C., Gagnon, E., Hatsuzawa, K., Thibault, P. and Desjardins, M. (2012). Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Mol Cell Proteomics 11, pp. M111 016378 https://www.ncbi.nlm.nih.gov/pubmed/22427703
Deleris, P., Trost, M., Topisirovic, I., Tanguay, P. L., Borden, K. L., Thibault, P. and Meloche, S. (2011). Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. J Biol Chem 286, pp. 6470-6478 https://www.ncbi.nlm.nih.gov/pubmed/21177870
Boulais, J.,* Trost, M.,* Landry, C. R., Dieckmann, R., Levy, E. D., Soldati, T., Michnick, S. W., Thibault, P. and Desjardins, M. (2010). Molecular characterization of the evolution of phagosomes. Mol Syst Biol 6, pp. 423 https://www.ncbi.nlm.nih.gov/pubmed/20959821
Trost, M., Bridon, G., Desjardins, M. and Thibault, P. (2010). Subcellular phosphoproteomics. Mass Spectrom Rev 29, pp. 962-90 https://www.ncbi.nlm.nih.gov/pubmed/20931658
Trunk, K., Benkert, B., Quack, N., Munch, R., Scheer, M., Garbe, J., Jansch, L., Trost, M., Wehland, J., Buer, J., Jahn, M., Schobert, M. and Jahn, D. (2010). Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons. Environ Microbiol 12, pp. 1719- 33 https://www.ncbi.nlm.nih.gov/pubmed/20553552
Trost M., English L., Lemieux S., Courcelles M., Desjardins M, Thibault P., The Phagosomal Proteome in IFN-g Activated Macrophages. Immunity. (2009) 30 (1):143-54. https://www.ncbi.nlm.nih.gov/pubmed/19144319
Topisirovic I., Siddiqui N., Lapointe L., Trost M., Thibault P., Piñol-Roma S., Borden K.L.B., Molecular Dissection of the mRNA export competent eIF4E RNP, EMBO Journal. (2009) 22 (8), 1087-98 https://www.ncbi.nlm.nih.gov/pubmed/19262567
Marcantonio M, Trost M, Courcelles M, Desjardins M, Thibault P., Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses. Mol Cell Proteomics. (2008) 7 (4): 645-60 https://www.ncbi.nlm.nih.gov/pubmed/18006492
Layer G, Pierik AJ, Trost M, Rigby SE, Leech HK, Grage K, Breckau D, Astner I, Jansch L, Heathcote P, Warren MJ, Heinz DW, Jahn D. (2006). The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN. J Biol Chem. (2006) 281(23):15727-34 https://www.ncbi.nlm.nih.gov/pubmed/16606627
Jacobsen I, Hennig-Pauka I, Baltes N, Trost M, Gerlach GF. Enzymes involved in anaerobic respiration appear to play a role in Actinobacillus pleuropneumoniae virulence. Infect Immun. (2005) 73 (1):226. https://www.ncbi.nlm.nih.gov/pubmed/15618158
Trost M., Wehmhöner D., Kärst U., Dieterich G., Wehland J. , Jänsch L., Comparative proteome analysis of secretory proteins from pathogenic and nonpathogenic Listeria Proteomics (2005) 5 (6):1544-57. https://www.ncbi.nlm.nih.gov/pubmed/15838904
Borsch M., Diez M., Zimmermann B., Trost M., Steigmiller S., Graber P., Stepwise rotation of the γ-subunit of EFoF1-ATP synthase during ATP synthesis: a single-molecule FRET approach. SPIE (2003) Vol. 4962,11-21 https://www.spiedigitallibrary.org/conference-proceedings-of-spie/4962/0000/Stepwise-rotation-of-the-947-subunit-of-EF-0-F/10.1117/12.479554.short
Bierne, H., Mazmanian, S.K., Trost, M., Pucciarelli, M.G., Liu, G., Dehoux, P., Jansch, L., Garcia-del Portillo, F., Schneewind, O., and Cossart, P., Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence. Microbiol. (2002) 43: 869-881. https://www.ncbi.nlm.nih.gov/pubmed/11929538